Correlation between Vitamin D Receptor Gene FOKI and BSMI Polymorphisms and the Susceptibility to Pulmonary Tuberculosis in an Indonesian Batak-ethnic Population
ABSTRACT: to explore the role
of FokI and BsmI polymorphisms the VDR gene in the susceptibility to pulmonary tuberculosis
(PTB) in an Indonesian Batak ethnic population. Methods: matched case-control
study was conducted on 76 PTB patients and 76 healthy normal control. Genetic
polymorphisms of Vitamin D Receptor (VDR) gene were analysed using PCR-RFLP.
Results: the frequencies of FokI genotypes were FF 35.5%, Ff 55.3%, ff 9.2% for
PTB patients and FF 39.5%, Ff 44.7.% and ff 15.8% for normal control. The BsmI
genotypes frequencies were BB 0%, Bb 68.4%, bb 31.6% for TB patients and BB
2.6%, Bb 23.7% and bb 73.7% for control. There was no signifcant association
between FokI genotype and PTB (OR 1.39, 95% CI: 0.69-2.77 for Ff genotype and
OR 0.64, 95% CI: 0.22-1.86 for ff genotype). There was a signifcant association
between BsmI genotype and PTB; the bb genotype was associated with a decreased
risk to PTB (OR 0.22, 95% CI: 0.11-0.45). Conclusion: in Indonesian Batak
ethnic population, there was no association between FokI polymorphism of VDR
gene with host susceptibility to PTB. There was a signifcant association
between BsmI polymorphism of VDR gene; bb genotype was associated with a
decreased risk to PTB.
Author: Bintang Y.M. Sinaga,
Muhammad Amin, Yahwardiah Siregar, Sori M. Sarumpaet
Journal Code: jpkedokterangg140290
