Correlation between alkaline phosphatase, g-glutamyl transpeptidase, and bilirubin with interleukin-1b level in dogs with obstructive jaundice
ABSTRACT: Surgical management
in obstructive jaundice still contributes to signifcant morbidity and mortality.
One of complications following surgery in obstructive jaundice is sepsis. This complication
is caused by the toxic effects of bilirubin and bile salts, endotoxins,
bacterial translocation, modulation of the immune-inflammatory cascade,
decreased cellular immunity and/or nutritional status. Many studies have shown
the elevated inflammatory response indicator, interleukin-1 (IL-1b), in patients
with obstructive jaundice. However, only a few report described the association
between the indicators of obstructive jaundice (alkaline phosphatase [ALP],
g-glutamyl transpeptidase [GGT], and bilirubin) and the indicator of
inflammatory response (interleukin-1b [IL-1b]). This study aimed to investigate
the association between the indicator of obstructive jaundice (ALP, GGT, and bilirubin)
and the level of interleukin-1b (IL-1b) in dogs as the animal model. We
performedligation on distal common bile ducts (CBD) to produce a model of
obstructive jaundice. Every three days within a month, the blood samples from
ten dogs were extracted to determine the ALP, GGT, direct and total bilirubin,
and IL-1b levels. We found a signifcant correlation between the ALP and GGT
with IL-1b level with p-value of 0.036 (r=0.626) and 0.003 (r=0.826). However,
there was no association between the increased direct bilirubin with the IL-1b
level (p=0.068; r=0.537). Moreover, the increased level of ALP and GGT had a
strong correlation with the increased level of direct bilirubin with p-value of
0.004 (r=0.810) and p=0.011 (r=0.746). In conclusion, the increased level of
GGT was the strongest indicator for inflammatory response in dogs with
obstructive jaundice. Furthermore, the increased levels of GGT and ALP might
imply the development of obstructive jaundice in dogs.
Author: Nurcahya Setyawan,
Vicky S. Budipramana
Journal Code: jpkedokterangg150365
