Clinical Presentation and Laboratory Features in Pediatric Typhoid Fever Patient Susceptibility to First-line Antibiotic Therapy
Abstract: RTyphoid fever
remainsa serious health problem in the world. The main cause of this disease is
Salmonella enterica serovar Typhi. These microbes have developed resistance to
first-line antibiotics (chloramphenicol, ampicillin, and co-trimoksazol) since
1950. Clinical presentation and laboratory features conducted in children
infected with resistant strains tend to be more severe. The objective of this
study was to determine the differences of clinical presentation and laboratory
features in pediatric typhoid fever patient susceptibility to first-line
antibiotics.
Methods: This was an analytical cross-sectional study of total 119
typhoid fever children with positive blood culture of Salmonella Typhi based on
medical data in Department of Child Health Dr. Hasan Sadikin General Hospital,
Bandung during 2008–2012. Inclusion criteria included 76 patients with age
range 1–15 years old, given an antibiotic, and had susceptibility test done.
Numerical variable was the duration of fever in patients after given an
antibiotic. Categorical variable included hepatomegaly, diarrhea, platelet
count at admission, and leukocyte count at admission. Data were analyzed using
a Mann-Whitney and Chi-square test.
Results: There was no statistically significant difference in the
duration of fever, leucocyte count at admission, and thrombocyte count at
admission between sensitive and resistant response to chloramphenicol,
ampicillin, and co-trimoksazol (p>0.05). Leucocyte count at admission in
children with sensitive and resistant strain to ampicillin almost showed a
difference (p=0.07) but still not statistically significant difference.
Conclusions: There is no difference of clinical presentation and laboratory
features in pediatric typhoid fever patient susceptible to first-line
antibiotics.
Author: Dewi Ratnasari,
Djatnika Setiabudi, Lulu Eva Rakhmilla
Journal Code: jpkedokterangg150320
