Basal follicle stimulating hormone and leptin on the day of hCG administration predict successful fertilization in in vitro fertilization
Abstract: Successful pregnancy
in in vitro fertilization (IVF) program depends on multiple factors. This study
aimed to determine whether age, body mass index (BMI), basal follicle
stimulating hormone (FSH), estradiol, and leptin on the day of trigger
ovulation with human chorionic gonadotropin (hCG) might be used as predictor
for successful oocyte fertilization in in vitro fertilization (IVF) program.
Methods: This is a cross sectional study conducted in Yasmin Fertility
Clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Forty participating
patients underwent IVF program, excluding smokers, patients with diabetic,
morbid obesity, and severe oligospermia or azoospermia. Age, BMI, basal FSH,
estradiol, leptin on the day of hCG administration, oocyte count on oocyte
retrieval, the number of mature oocyte, and fertility rate were analyzed using
bivariate and multivariate analysis to determine which eligible factors play
role in predicting the successful of fertilization.
Results: Significant correlation was found between basal FSH level and
serum leptin/oocyte ratio on the day of hCG administration with successful
fertilization. We found probability formula as follows: 1/(1+exp –(6.2 -
0.4(leptin serum/oocyte ratio) - 0.8(basal FSH)), with 77.8% sensitivity, 77.8%
specificity, and AUC levels of 85.6% indicating strong predictability.
Probability of successful fertilization related to basal FSH level of 5.90
mIU/mL and leptin serum/oocyte ratio of 3.98.
Conclusion: The formula consisting of basal FSH and leptin serum/oocyte
ratio on the day of trigger ovulation was capable in predicting the probability
of successful fertilization in IVF procedure.
Author: Andon Hestiantoro,
Budi Wiweko, Robert H. Purwaka
Journal Code: jpkedokterangg160133