Antibiotic susceptibility of Salmonella, Shigella and Vibrio isolated from diarrhea patients in Jakarta, Indonesia
Abstract: The rapid increase
of antibiotic resistance among enteric pathogens in developing countries has
become a great concern. In Indonesia, Salmonella, Shigella, and Vibro are still
an important public health problem.
Objectives: The purpose of this study was to determine the antibiotic resistance
patterns of several diarrhea-causing enteric bacteria that are frequently found
in Indonesia, particularly Salmonella, Shigella and Vibrio.
Methods: A cross-sectional study was conducted , among 150 rectal swabs
collected from patients with diarrhea, the enteric pathogens isolated comprised
Shigella (11.4%), Salmonella (6.6%) and Vibrio (2.7%).
Results: Antibiotic susceptibility test on Shigella species to several antibiotics
such as ampicillin, chloramphenicol, tetracycline and , trimethoprim-sulfamethoxazole
showed a considerably high resistance rate (25%-100%), whereas ceftriaxone,
ciprofloxacin, norfloxacinand nalidixic acid were apparently still effective
(resistance rate 0%). Non-typhoid Salmonella had similar resistance patterns as
those of Shigella, particularly to ampicillin, tetracycline, chloramphenicol
and trimethoprim- sulfamethoxazole However, for S. typhi it was found that all
antibiotics were still effective. Vibrio was resistant to ampicillin (resistance
rate 100%), whereas the other antibiotics were still effective.
Conclusion: It may be concluded that for each of the enteric pathogens the
antibiotic resistance pattern should be determined. Use of antibiotics should
be based on the antibiotic susceptibility tests.
Author: Meiyanti, Oktavianus
Ch. Salim, Elly Herwana , Joice V.Kalumpiu, Murad Lesmana
Journal Code: jpkedokterangg160162