Abstract: The rapid increase of antibiotic resistance among enteric pathogens in developing countries has become a great concern. In Indonesia, Salmonella, Shigella, and Vibro are still an important public health problem.
Objectives: The purpose of this study was to determine the antibiotic resistance patterns of several diarrhea-causing enteric bacteria that are frequently found in Indonesia, particularly Salmonella, Shigella and Vibrio.
Methods: A cross-sectional study was conducted , among 150 rectal swabs collected from patients with diarrhea, the enteric pathogens isolated comprised Shigella (11.4%), Salmonella (6.6%) and Vibrio (2.7%).
Results: Antibiotic susceptibility test on Shigella species to several antibiotics such as ampicillin, chloramphenicol, tetracycline and , trimethoprim-sulfamethoxazole showed a considerably high resistance rate (25%-100%), whereas ceftriaxone, ciprofloxacin, norfloxacinand nalidixic acid were apparently still effective (resistance rate 0%). Non-typhoid Salmonella had similar resistance patterns as those of Shigella, particularly to ampicillin, tetracycline, chloramphenicol and trimethoprim- sulfamethoxazole However, for S. typhi it was found that all antibiotics were still effective. Vibrio was resistant to ampicillin (resistance rate 100%), whereas the other antibiotics were still effective.
Conclusion: It may be concluded that for each of the enteric pathogens the antibiotic resistance pattern should be determined. Use of antibiotics should be based on the antibiotic susceptibility tests.
Author: Meiyanti, Oktavianus Ch. Salim, Elly Herwana , Joice V.Kalumpiu, Murad Lesmana
Journal Code: jpkedokterangg160162