Angiogenesis, Inflammation, Platelets Count, and Metastatic Status as a Predictor for Thrombosis Risk in Nasopharyngeal Carcinoma Patients
ABSTRACT: to assess the use of
of angiogenesis, inflammation, platelets count, and metastatic status as
predictors for thrombosis risk represented by soluble P-selectin level in nasopharyngeal
carcinoma (NPC) patients. Methods: a cross sectional study was conducted on NPC
patients at the Hematology and Oncology Clinic of Cipto Mangunkusumo Hospital,
Jakarta, during Mei to October 2012. Data regarding angiogenesis (CD105 and
VEGFR-2), inflammation (IL-6), platelets count, and metastatic status were
assessed at enrollment, as well as soluble P-selectin levels in all eligible
patients. Bivariate analysis continued with multiple linear regression analysis
were done to identify independent predictors for soluble P-selectin levels.
Results: sixty NPC patients were enrolled in the study. There was correlation
between platelet counts (r=0.389; p=0.002), IL-6 (r=0.595; p<0.001) and
number of metastatic sites (r=0.542; p<0.001) with soluble P-selectin level,
and a linear regression analysis showed that these three variables can predict
soluble P-selectin levels with adjusted R-square 65%. There was no correlation
between VEGFR-2 and CD105 levels with soluble P-selectin levels. Conclusion:
platelet counts, IL-6 level, and number of sites of metastasis can be used as
predictors of soluble P-selectin level as parameter of thrombosis risk in NPC
patients.
Author: Aru W. Sudoyo, Andhika
Rachman, Kuntjoro Harimurti
Journal Code: jpkedokterangg150250
