A COMPARISON BETWEEN THE EFFECTIVENESS OF THE ETHANOL BASED EXTRACT OF POMEGRANATE PEEL (PUNICA GRANATUM) AND SIMVASTATIN DRUG FOR LOWERING BLOOD LDL LEVEL IN HYPERCHOLESTEROLEMIC MALE RATS (RATTUS NOVERGICUS)
Abstract: Hypercholesterolemia
is one of the major risk factors for coronary heart disease. Drugs of natural
pomegranate peel extract using ethanol can be used as an alternative of
simvastatin as standard drugs. Preclinical trials are needed before clinical
trials in humans to ensure the efficacy of the drug from the nature.
Objective: To compare effectiveness of pomegranate peel extract using
ethanol (Punica granatum) with simvastatin for lowering LDL level in
hypercholesterolemia white rats (Rattus novergicus).
Methods: This study used an experimental research design with
pretestposttest control group. We use 27 male hypercholesterolemia wistar
strain rats were used as samples. The samples were divided into 3 groups. Group
I as a negative control was given DMSO 2% 2ml/300gramBW, group II was
given simvastatine 0.18 mg/200gramBB/day, group III was given ethanol
extract of pomegranate peel 30mg/200gramBB/day for 15 days.
Results: Results of paired t-test showed that the group treated with
simvastatin decreased LDL levels significantly. The group treated with ethanol
extract of pomegranate peel decreased LDL levels significantly. The group given
the ethanol extract did not decrease LDL levels significantly.
Conclusion: Extract of pomegranate peel using ethanol is not effective
for lowering LDL levels in hypercholesterolemia white rats (Rattus novergicus)
compared to simvastatin.
Author: Pitra Mukhlis Wardani,
Putrya Hawa
Journal Code: jpkedokterangg150345