Potensi Rumput Laut Coklat Jenis Sargassum duplicatum yang berasal dari Perairan Menganti-Kebumen sebagai Antiagregasi Platelet
ABSTRACT: A study concerning
the potential of brown seaweed of Sargassum duplicatum from Menganti beach-Kebumen
as anti-platelet aggregation was investigated. Anti-platelet aggregation test performed
in vitro using human blood with a Born method, is based on changes in light transmission
with Adenosine Diphosphat (ADP) 10 µL added as an inductor. Tests performed on
extracts and fractions of Sargassum duplicatum using positive control acetyl
salicylic acid 80 mg / mL. The test results of the anti-platelet aggregation of
Sargassum duplicatum extract concentration 125 µg /mL, 250 µg /mL, 500 µg /mL,
n-hexane fraction 500 µg /mL, the ethyl acetate fraction 500 µg /mL, and water
fraction 500 µg/mL, respectively gives a value of 4.68%, 6.77%, 11.64%, 55.51%,
52.10% and -1.55%. Whereas the positive control acetyl salicylic acid 8µug /mL
give 48.49% inhibitory. based on these results it can be concluded that the
fraction n-hexane of Sargassum duplicatum shows anti-platelet aggregation
activity of the most optimal. Phytochemical test showed n-hexane fraction
containing flavonoids, monoterpenoid, seskuiterpenoid, steroids and quinones.
Penulis: Dewanto, Siti
Mutripah, Yoppi Iskandar dan Melisa Intan Barliana
Kode Jurnal: jpperikanandd130232
