SUSU KEDELAI MENURUNKAN RESISTENSI INSULIN PADA MODEL DIABETES MELITUS TIPE 2
ABSTRACT: Type 2 Diabetes
mellitus (T2DM) is characterized by hyperinsulinemia and hyperglicemia. Soy
bean Milk ishigh nutrient drink, especially its protein contain. Several
researches demonstrated that soy bean proteindecrease plasma insulin and blood
glucose level. The aim of this study is to investigate the effect of soy
beanmilk in reducing insulin resistance of rat T2DM Model. This experimental
study used pre and post test controlgroup design. Male Rattus norvegicus wistar
strain 8 week old were used as animal model. T2DM rats wereconstructed by
giving high fat diet and continue with injection of low dose of streptozotocin.
Rats were dividedinto 7 groups (1) Negative control group (2) Positive control
group (T2DM rat without soy bean milk) (3) T2DMrat that treated with genistein
15 g/kgBW (4) T2DM rat that treated with soy bean milk 10 ml/kgBW/day (5)DMT2
rat that treated with soy bean milk 30 ml/kgBW/day (6) T2DM rat that treated
with soy bean milk 60ml/kgBW/day and (7) T2DM rat that treated with soy bean
milk 90 ml/kgBW/day. Soy bean milk was administrated for 15 days. Data were
analyze using One way ANOVA, than continue with Tukey test by SPSS method 13
Version. The result showed that there were a significant effect of soy bean
milk in decreasing glucose serum level (p=0.02) and insulin plasma level
(p=0.00). A High increasing of glucose serum level and insulin plasma level
occur when rat of DMT2 model was given soy bean milk 90 ml/kgBW/d.
Penulis: Wiwik Handayani,
Ahmad Rudijanto, Mohammad Rasjad Indra
Kode Jurnal: jpkedokterandd090128
