Induksi Meningkatkan Proporsi Endotelin-1 pada Aorta Mencit yang Diinduksi Diet Aterogenik Porphyromonas gingivalis
ABSTRACT: One of the risk
factor of atherosclerosis is associated with activation of the inflammatory
process in infection, as evidence by systemic elevations of molecules such as
MCP-1,PAI-1 and ET-1. Recent evidence suggests that infectious agents,
including those that cause periodontal disease, may also important role in atherosclerosis.
The aim of this study was to determine if recurrent intravenous injections with
P. gingivalis for 14 weeks promotes endothelial smooth muscle ET-1 proportion
in aortic mice. Twenty four weeks old mice (n=6 per group for each time point)
were divided in two groups, there were normal diet and atherogenic diet,each of
them were inoculated intravenously with live P. gingivalis (10 cell/50µl PBS)
injections or vehicle (50µl PBS) once per week for 14 weeks. The
Immunohistochemistry for aortic ET-1 proportion were performed. The result of
RAK with 3 interaction and Tukey test using SPSS 14 for windows showed that at
14 weeks, theET-1 proportion in aortic endothelial cell was higher than in
aortic smooth muscle cell. Recurrent P. gingivalis bacteremia in normodiet and
atherodiet was proportion of ET-1 in aortic endothelial cell was higher than in
aortic smooth muscle cell. In can be concluded that Induction of P. gingivalis
increase proportion of aortic's ET-1 in atherodiet mice.
Penulis: Helmin Elyani, Tinny
Endang Hernowati, Sumarno
Kode Jurnal: jpkedokterandd090129
